The most common and most likely answer to this crossword clue is the 4 plus 7 letter word COME UNSTUCK
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More clues leading to the result COME UNSTUCK
Buddy explains!
The straight part
We know that "Lose one’s grip/ and /experience a setback/? (4,7)" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case lose one’s grip/ and /experience a setback/? (4,7) = come unstuck.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.