Cryptic crossword clue
Lose sympathy of stranger, at ease initially? 8

The most common and most likely answer to this crossword clue is the 8 letter word ALIENATE

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Buddy explains!

The straight part
We know that "Lose sympathy of" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case lose sympathy of = alienate.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ALIENATE mean?

ALIENATE noun
  1. A stranger; an alien.
ALIENATE verb
  1. To convey or transfer to another, as title, property, or right; to part voluntarily with ownership of.
  2. To estrange; to withdraw affections or attention from; to make indifferent or averse, where love or friendship before subsisted.
ALIENATE adjective
  1. (followed by "from") Estranged; withdrawn in affection; foreign

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