Cryptic crossword clue
Losing potency, facing defeat in struggle 14

The most common and most likely answer to this crossword clue is the 14 letter word DECAFFEINATING

D
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Buddy explains!

The straight part
We know that "Losing potency" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case losing potency = decaffeinating.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DECAFFEINATING mean?

DECAFFEINATING verb
  1. To remove the caffeine from something (especially from coffee).

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