The most common and most likely answer to this crossword clue is the 6 letter word PLENTY
I've seen this crossword clue in The Guardian
P
L
E
N
T
Y
More clues leading to the result PLENTY
- Lots of work around hospital department
- Forty days and nights in Paraguay's borders? That's quite enough!
- Fast time in ‘hollow penis surgery’? That’s quite enough!
- Lots to go with the horn?
- Hospital department divides to provide a sufficient amount
- Work steadily at keeping hospital department in full supply
- A lot of work outside part of Guy’s?
- Dozens and dozens work around hospital department
- Quiet Yankee eats fast enough
- Hospital department put in place year full of supply
Buddy explains!

The straight part
We know that "Lots" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case lots = plenty.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does PLENTY mean?
PLENTY noun- A more-than-adequate amount.
- Plentiful
- More than sufficiently.
- Used as an intensifier, very.
- More than enough.