Cryptic crossword clue
Loud noise, ultimately in head, may do so 6

The most common and most likely answer to this crossword clue is the 6 letter word DEAFEN

I've seen this crossword clue in The Times
D
E
A
F
E
N


Buddy explains!

The straight part
We know that "Loud noise, ultimately in head, may do so" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case loud noise, ultimately in head, may do so = deafen.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DEAFEN mean?

DEAFEN verb
  1. To make deaf, either temporarily or permanently.
  2. To make soundproof.
  3. (sometimes figurative) To stun, as with noise.

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