The most common and most likely answer to this crossword clue is the 6 letter word COOTIE
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More clues leading to the result COOTIE
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does COOTIE mean?
COOTIE noun- A louse (Pediculus humanus).
- A louse (Pediculus humanus).
- (usually in the plural) Any germ or contaminant, real or imagined, especially from the opposite gender (for pre-pubescent children).
- A nest-building female American coot (counterpart to cooter).
- A sideswiper, a type of telegraph key.