Cryptic crossword clue
Lousy home made much of welcoming son 8

The most common and most likely answer to this crossword clue is the 8 letter word INFESTED

I've seen this crossword clue in The Times
I
N
F
E
S
T
E
D

Buddy explains!

The straight part
We know that "Lousy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case lousy = infested.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INFESTED mean?

INFESTED verb
  1. To inhabit a place in unpleasantly large numbers; to plague, harass.
  2. (of a parasite) To invade a host plant or animal.

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