Cryptic crossword clue
LSD fired up musicians

The most common and most likely answer to this crossword clue is the 8 letter word FIDDLERS

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "musicians" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case musicians = fiddlers.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FIDDLERS mean?

FIDDLERS noun
  1. One who plays the fiddle.
  2. One who fiddles.
  3. A burrowing crab of the genus Gelasimus, of many species. The male has one claw very much enlarged, and often holds it in a position similar to that in which a musician holds a fiddle.
  4. The common European sandpiper (Actitis hypoleucos); so called because it continually oscillates its body.

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