The most common and most likely answer to this crossword clue is the 7 letter word BERSERK
I've seen this crossword clue in The Guardian
B
E
R
S
E
R
K
More clues leading to the result BERSERK
Buddy explains!

The straight part
We know that "Mad" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case mad = berserk.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does BERSERK mean?
BERSERK noun- A crazed Norse warrior who fought in a frenzy; a berserker.
- Injuriously, maniacally, or furiously violent or out of control.
- Weird; bizarre.