Cryptic crossword clue
Mad rant by old writer associated with timeless pop is a downer 13

The most common and most likely answer to this crossword clue is the 13 letter word TRANQUILLIZER

I've seen this crossword clue in The Daily Telegraph
T
R
A
N
Q
U
I
L
L
I
Z
E
R

Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TRANQUILLIZER mean?

TRANQUILLIZER noun
  1. That which tranquillizes or soothes.
  2. A drug used to reduce anxiety or tension; a sedative.

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