Cryptic crossword clue
Made more fretful when US ignored complicated heuristic 7

The most common and most likely answer to this crossword clue is the 7 letter word ITCHIER

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Buddy explains!

The straight part
We know that "more fretful" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case more fretful = itchier.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ITCHIER mean?

ITCHIER adjective
  1. Having or creating an itch, causing a person or animal to tend to want to scratch.

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