Cryptic crossword clue
Made more sour beer in Eastern Mediterranean 10

The most common and most likely answer to this crossword clue is the 10 letter word EMBITTERED

I've seen this crossword clue in The Daily Telegraph
E
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Buddy explains!

The straight part
We know that "Made more sour" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case made more sour = embittered.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EMBITTERED mean?

EMBITTERED verb
  1. To cause to be bitter.

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