Cryptic crossword clue
Maiden is leading supporting song, creating trouble 10

The most common and most likely answer to this crossword clue is the 10 letter word MISFORTUNE

I've seen this crossword clue in The Daily Telegraph
M
I
S
F
O
R
T
U
N
E

Buddy explains!

The straight part
We know that "trouble" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case trouble = misfortune.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

MISFORTUNE noun
  1. Bad luck
  2. An undesirable event such as an accident

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