The most common and most likely answer to this crossword clue is the 12 letter word QUINTESSENCE
Q
U
I
N
T
E
S
S
E
N
C
E
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does QUINTESSENCE mean?
QUINTESSENCE noun- A thing that is the most perfect example of its type; the most perfect embodiment of something; epitome, prototype.
- A pure substance.
- The essence of a thing in its purest and most concentrated form.
- The fifth alchemical element, or essence, after earth, air, fire, and water
- A hypothetical form of dark energy postulated to explain observations of an accelerating universe.
- To reduce to its purest and most concentrated essence.