The most common and most likely answer to this crossword clue is the 8 letter word ATLANTIC
I've seen this crossword clue in The Daily Telegraph
A
T
L
A
N
T
I
C
More clues leading to the result ATLANTIC
- Mrs Partington's main opponent
- Where American, for one, lost in doomed Titanic
- Cat-o’-nine-tails remarkably noiseless in the ocean
- Duke leaving country in Greek liner might cross it
- A lot of water in room upstairs – get daughter out
- Main network in roof space
- Cat-o’-nine-tails remarkably noise-less in ocean
- Finally reversing direction towards end avoids unknown part of frozen ocean
- Country mostly found in Greek body of water?
- Main computer network in roof space
Buddy explains!

The straight part
We know that "Main" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case main = atlantic.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.