The most common and most likely answer to this crossword clue is the 4 letter word ENTR
I've seen this crossword clue in The Sunday Telegraph
E
N
T
R
More clues leading to the result ENTR
- Course held in centre ended
- Main course in middle of menu, something woody
- Item for middle of play requiring space in middle of scenery
- Music centre at which ____’s played?
- Course taken by some in parliament re-elected
- Interlude with silly utterances putting us off
- Admission in French service maybe
- Car teen trashed round street’s end in dramatic interlude
- English racing venue not top-class course
- Admission to course
Buddy explains!
The straight part
We know that "Main course" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case main course = entr.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.