The most common and most likely answer to this crossword clue is the 7 letter word OCTOPUS
I've seen this crossword clue in The Guardian
O
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T
O
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More clues leading to the result OCTOPUS
- Powerful body’s miserable cop-outs
- Ceramic business set up by American organisation with influence
- Autumn work for army type
- Far-reaching organisation can tempt others at first into work
- Month to get work for army type, in the main?
- In several weeks work one may use a lot of ink
- Old copper’s protecting best swimmer
- One with great influence over court work
- Commander leading American organisation that seems to be everywhere
- Seafood dish of the month followed by canned soup
Buddy explains!

The straight part
We know that "Main inhabitant" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case main inhabitant = octopus.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does OCTOPUS mean?
OCTOPUS noun- Any of several marine molluscs of the family Octopodidae, having no internal or external protective shell or bone (unlike the nautilus, squid and cuttlefish) and eight arms each covered with suckers.
- The flesh of these marine molluscs eaten as food.
- An organization that has many powerful branches controlled from the centre.
- To put (or attempt to put) one's fingers, hands or arms in many things or places at roughly the same time.
- To spread out in long arms or legs in many directions.
- To plug a large number of devices into a single electric outlet.
- (by extension) To grow in use vastly beyond what was originally intended.
- To hunt and catch octopuses.
- To behave like an octopus.