The most common and most likely answer to this crossword clue is the 4 plus 3 letter word OPEN SEA
I've seen this crossword clue in Independent
O
P
E
N
S
E
A
More clues leading to the result OPEN SEA
- Start to notice, we hear, area away from land
- Endless ocean having restricted places for carbon?
- Main operation’s getting partners to enter single market body
- A lot of water around in buffalo pens earlier
- Operation seen in a new light, on a body of water away from land
- Golf tournament spot, reportedly somewhere far out in the main
- Frank Ocean in the middle of nowhere
Buddy explains!

The straight part
We know that "Main" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case main = open sea.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.