Cryptic crossword clue
Main pressure contains opening of main sewer 10

The most common and most likely answer to this crossword clue is the 10 letter word SEAMSTRESS

I've seen this crossword clue in The Daily Telegraph
S
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Buddy explains!

The straight part
We know that "sewer" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case sewer = seamstress.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEAMSTRESS mean?

SEAMSTRESS noun
  1. A woman who sews clothes professionally.

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