Cryptic crossword clue
Main song line directed at the audience 5

The most common and most likely answer to this crossword clue is the 5 letter word ASIDE

I've seen this crossword clue in Financial Times
A
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Buddy explains!

The straight part
We know that "line directed at the audience" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case line directed at the audience = aside.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ASIDE mean?

ASIDE noun
  1. An incidental remark made quietly so as to be heard by the person to whom it is said and not by any others in the vicinity.
  2. A brief comment by a character addressing the audience, unheard by other characters.
  3. A minor related mention, an afterthought.
ASIDE adverb
  1. To or on one side so as to be out of the way.

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