Cryptic crossword clue
Maine theatre containing large old organ 8

The most common and most likely answer to this crossword clue is the 8 letter word MELODEON

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Buddy explains!

The straight part
We know that "old organ" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case old organ = melodeon.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MELODEON mean?

MELODEON noun
  1. A music hall.
MELODEON noun
  1. A type of reed organ with a single keyboard.
  2. An accordion where the melody-side keyboard is limited to the notes of diatonic scales in a small number of keys.

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