Cryptic crossword clue
Maintain a sizeable lock-up 6

The most common and most likely answer to this crossword clue is the 6 letter word ASSERT

I've seen this crossword clue in The Times
A
S
S
E
R
T


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The straight part
We know that "Maintain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case maintain = assert.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ASSERT mean?

ASSERT noun
  1. An assertion; a section of source code which tests whether an expected condition is true.
ASSERT verb
  1. To declare with assurance or plainly and strongly; to state positively.
  2. To use or exercise and thereby prove the existence of.
  3. To maintain or defend, as a cause or a claim, by words or measures; to vindicate a claim or title to
  4. To specify that a condition or expression is true at a certain point in the code.
  5. To set a signal on a line using a voltage or electric current.

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