The most common and most likely answer to this crossword clue is the 3 letter word OPT
I've seen this crossword clue in The Times
O
P
T
More clues leading to the result OPT
- Make a choice — work ahead of time
- With zero exercise get plump
- Plump and old, needing exercise?
- Oscar has drill and pick
- Choose to back first of 26, dropping odds
- Choose to back, seizing power
- Choose filling of Pop Tarts
- Choose the best without mother and me
- Settle old vacant plot
- Choose Pop-Tarts with no bits on
Buddy explains!

The straight part
We know that "Make a choice" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make a choice = opt.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does OPT mean?
OPT verb- To choose; select.