Cryptic crossword clue
Make a strenuous effort to disregard hint of presumption in scientific witness 5

The most common and most likely answer to this crossword clue is the 5 letter word EXERT

I've seen this crossword clue in Independent
E
X
E
R
T


Buddy explains!

The straight part
We know that "Make a strenuous effort" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make a strenuous effort = exert.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does EXERT mean?

EXERT verb
  1. To put in vigorous action.
  2. To make use of, to apply, especially of something non-material.

Latest crossword clues with full explanations