Cryptic crossword clue
Make best use of work — time is flexible 8

The most common and most likely answer to this crossword clue is the 8 letter word OPTIMISE

I've seen this crossword clue in The Daily Telegraph
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Buddy explains!

The straight part
We know that "Make best use of" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make best use of = optimise.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

Crossword Answer definitions

OPTIMISE verb
  1. (originally intransitive) To act optimistically or as an optimist.
  2. To make (something) optimal.
  3. To make (something) more efficient, such as a computer program.
  4. To become optimal.

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