The most common and most likely answer to this crossword clue is the 6 letter word CREATE
I've seen this crossword clue in The Times
C
R
E
A
T
E
More clues leading to the result CREATE
- Make large container carrying eggs, principally
- Make box for holding tablet
- A holiday island’s round coin
- Produce box filled with quince at last
- . Make a fuss about extreme hike in tariff
- . Make of old aircraft with the letter E in it
- Found ecstasy in container
- Produce animal with no sign of hesitation
- Case involving European institute
- Porsche finally stopping old car design
Buddy explains!

The straight part
We know that "Make" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make = create.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CREATE mean?
CREATE verb- To bring into existence; (sometimes in particular:)
- To cause, to bring (a non-object) about by an action, behavior, or event, to occasion.
- To confer or invest with a rank or title of nobility, to appoint, ordain or constitute.
- To be or do something creative, imaginative, originative.
- In theatre, to be the first performer of a role; to originate a character.
- To make a fuss, complain; to shout.
- Created, resulting from creation.