Cryptic crossword clue
Make certain of being on river 6

The most common and most likely answer to this crossword clue is the 6 letter word ENSURE

I've seen this crossword clue in The Daily Telegraph
E
N
S
U
R
E


Buddy explains!

The straight part
We know that "Make certain of" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make certain of = ensure.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENSURE mean?

ENSURE verb
  1. To make a pledge to (someone); to promise, guarantee (someone of something); to assure.
  2. To make sure or certain of something (usually some future event or condition).

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