Cryptic crossword clue
Make heavy demands on adult groups in biology 4

The most common and most likely answer to this crossword clue is the 4 letter word TAXA

T
A
X
A

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The straight part
We know that "groups in biology" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case groups in biology = taxa.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TAXA mean?

TAXA noun
  1. A group of one or more populations of an organism or organisms seen by taxonomists to form a unit.

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