Cryptic crossword clue
Make light of vocalise not about two notes in it 10

The most common and most likely answer to this crossword clue is the 10 letter word VOLATILISE

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Buddy explains!

The straight part
We know that "Make light" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make light = volatilise.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VOLATILISE mean?

VOLATILISE verb
  1. To make volatile; to cause to evaporate.
  2. To make insubstantial; to dissipate.
  3. To become volatile; to evaporate.

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