The most common and most likely answer to this crossword clue is the 5 plus 4 letter word BREAK EVEN
I've seen this crossword clue in The Daily Telegraph
B
R
E
A
K
E
V
E
N
More clues leading to the result BREAK EVEN
Buddy explains!
The straight part
We know that "Make neither profit nor loss" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make neither profit nor loss = break even.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does BREAK EVEN mean?
BREAK EVEN noun- The level of revenues sufficient to cover costs.
- That is characterized by the level of revenues just sufficient to cover costs