The most common and most likely answer to this crossword clue is the 6 letter word DECODE
I've seen this crossword clue in The Guardian
D
E
C
O
D
E
More clues leading to the result DECODE
- Unscramble lyric after a month
- Interpret letter describing how goods may be delivered
- Crack fish in river
- Untangle fish in river
- Fathom the meaning of last month’s poem
- Interpret Christmas poem?
- Find the solution for fish in river
- Enigma’s output and what to do with it?
- Make sense of Christmas poem?
- Interpret Advent or Christmas poem?
Buddy explains!

The straight part
We know that "Make sense" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make sense = decode.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DECODE mean?
DECODE noun- A product of decoding
- Output from a program or device used to interpret communication protocols
- To convert from an encrypted form to plain text.
- To figure out something difficult to interpret.