Cryptic crossword clue
Make susceptible drunk sip red with model 10

The most common and most likely answer to this crossword clue is the 10 letter word PREDISPOSE

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "Make susceptible" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make susceptible = predispose.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PREDISPOSE mean?

PREDISPOSE verb
  1. To make someone susceptible to something (such as a disease).
  2. To make someone inclined to something in advance; to influence.

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