The most common and most likely answer to this crossword clue is the 7 letter word CONFECT
I've seen this crossword clue in The Times
C
O
N
F
E
C
T
Buddy explains!

The straight part
We know that "Make" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make = confect.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CONFECT mean?
CONFECT noun- A rich, sweet, food item made of flavored sugar and often combined with fruit or nuts; a confection, comfit.
- To make up, prepare, or compound; to produce by combining ingredients or materials; to concoct.
- To make into a confection; to prepare as a candy, sweetmeat, preserve, or the like.