Cryptic crossword clue
Make unsuitable kind of music without Portishead’s leaders on board 9

The most common and most likely answer to this crossword clue is the 9 letter word INDISPOSE

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does INDISPOSE mean?

INDISPOSE verb
  1. To render unfit or unsuited; to disqualify.
  2. To make indisposed, or slightly unwell.
  3. To disincline.

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