The most common and most likely answer to this crossword clue is the 7 letter word CONCOCT
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More clues leading to the result CONCOCT
Buddy explains!

The straight part
We know that "Make up" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case make up = concoct.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does CONCOCT mean?
CONCOCT verb- To prepare something by mixing various ingredients, especially to prepare food for cooking.
- To contrive something using skill or ingenuity.
- To digest.