Cryptic crossword clue
Makes certain to blame son if cocaine goes missing 7

The most common and most likely answer to this crossword clue is the 7 letter word ENSURES

I've seen this crossword clue in The Guardian
E
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Buddy explains!

The straight part
We know that "Makes certain" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case makes certain = ensures.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ENSURES mean?

ENSURES verb
  1. To make a pledge to (someone); to promise, guarantee (someone of something); to assure.
  2. To make sure or certain of something (usually some future event or condition).

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