The most common and most likely answer to this crossword clue is the 8 letter word DERANGES
I've seen this crossword clue in The Guardian
D
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More clues leading to the result DERANGES
Buddy explains!

The straight part
We know that "Makes crazy" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case makes crazy = deranges.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does DERANGES mean?
DERANGES verb- (chiefly passive) To cause (someone) to go insane or become deranged.
- To cause disorder in (something); to distort from its ideal state.
- To disrupt somebody's plans, to inconvenience someone; derail.