Cryptic crossword clue
Making children squeal, I run inside 6

The most common and most likely answer to this crossword clue is the 6 letter word SIRING

I've seen this crossword clue in The Guardian
S
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R
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Buddy explains!

The straight part
We know that "Making children/Making children" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case making children/making children = siring.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SIRING mean?

SIRING verb
  1. (of a male) to procreate; to father, beget, impregnate.
SIRING noun
  1. An act of procreation, especially between animals.

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