Cryptic crossword clue
Making too much effort, wander beginning to end, tire oxen out 12

The most common and most likely answer to this crossword clue is the 12 letter word OVEREXERTION

I've seen this crossword clue in Financial Times
O
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Buddy explains!

The straight part
We know that "Making too much effort/Making too much effort" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case making too much effort/making too much effort = overexertion.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

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