Cryptic crossword clue
Malign six cut biography unfairly in end 6

The most common and most likely answer to this crossword clue is the 6 letter word VILIFY

I've seen this crossword clue in Financial Times
V
I
L
I
F
Y

Buddy explains!

The straight part
We know that "Malign" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case malign = vilify.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does VILIFY mean?

VILIFY verb
  1. To say defamatory things about someone or something; to speak ill of.
  2. To belittle through speech; to put down.

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