The most common and most likely answer to this crossword clue is the 8 letter word TIMIDEST
I've seen this crossword clue in The Times
T
I
M
I
D
E
S
T
More clues leading to the result TIMIDEST
Buddy explains!
The straight part
We know that "most like a mouse" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case most like a mouse = timidest.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TIMIDEST mean?
TIMIDEST adjective- Lacking in courage or confidence.