Cryptic crossword clue
Man U get beaten by Spurs at last! They will make changes 8

The most common and most likely answer to this crossword clue is the 8 letter word MUTAGENS

I've seen this crossword clue in Independent
M
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MUTAGENS mean?

MUTAGENS noun
  1. Any agent or substance that can cause genetic mutation.

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