Cryptic crossword clue
Managed most of trial venue in spite 7

The most common and most likely answer to this crossword clue is the 7 letter word RANCOUR

I've seen this crossword clue in The Times
R
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The straight part
We know that "spite" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case spite = rancour.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RANCOUR mean?

RANCOUR noun
  1. The deepest malignity or spite; deep-seated enmity or malice; inveterate hatred.

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