Cryptic crossword clue
Man’s hot spirit — sadly he dislikes his fellows 13

The most common and most likely answer to this crossword clue is the 13 letter word MISANTHROPIST

I've seen this crossword clue in The Daily Telegraph
M
I
S
A
N
T
H
R
O
P
I
S
T

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does MISANTHROPIST mean?

MISANTHROPIST noun
  1. A misanthrope; a person who hates all humankind.

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