Cryptic crossword clue
Mark loses heart in a state of stupor 4

The most common and most likely answer to this crossword clue is the 4 letter word COMA

C
O
M
A


Buddy explains!

The straight part
We know that "state of stupor" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case state of stupor = coma.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does COMA mean?

COMA noun
  1. A state of unconsciousness from which one may not wake up, usually induced by some form of trauma.
COMA noun
  1. A cloud of dust surrounding the nucleus of a comet.
  2. A defect characterized by diffuse, pear-shaped images that in an ideal image would appear as points.
  3. A tuft or bunch, such as the assemblage of branches forming the head of a tree, a cluster of bracts when empty and terminating the inflorescence of a plant, or a tuft of long hairs on certain seeds.

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