Cryptic crossword clue
markedly different from the norm

The most common and most likely answer to this crossword clue is the 8 letter word ABERRANT

I've seen this crossword clue in The Guardian
A
B
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R
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ABERRANT mean?

ABERRANT noun
  1. A person or object that deviates from the rest of a group.
  2. A group, individual, or structure that deviates from the usual or natural type, especially with an atypical chromosome number.
ABERRANT adjective
  1. Differing from the norm.
  2. (sometimes figurative) Straying from the right way; deviating from morality or truth.
  3. Deviating from the ordinary or natural type; exceptional; abnormal.

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