The most common and most likely answer to this crossword clue is the 12 letter word MISADVENTURE
M
I
S
A
D
V
E
N
T
U
R
E
More clues leading to the result MISADVENTURE
- Plug hole in motorway certain to produce accident
- Tortuous drive meant us having accident
- Motorway’s approach over Yorkshire river leads to accident
- Calamity Jane finally after varmints due to blow
- I’m getting over second season on river bringing bad luck
- Motorway certain to choke most of December – bad luck!
- . I'm turning down volume, electronic tuner suffered failure
- Married ones nowadays risk failure
- Motorway bound to include coming accident
- Arrival into major road bound to result in an accident
Buddy explains!

The straight part
We know that "failure" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case failure = misadventure.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does MISADVENTURE mean?
MISADVENTURE noun- An accidental mishap or misfortune.