Cryptic crossword clue
Masterly publication is virtually unlikely to accept minimum of responsibility 9

The most common and most likely answer to this crossword clue is the 9 letter word MAGISTRAL

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Buddy explains!

The straight part
We know that "Masterly" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case masterly = magistral.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does MAGISTRAL mean?

MAGISTRAL noun
  1. A sovereign medicine or remedy.
  2. A magistral line.
  3. Powdered copper pyrites used in the amalgamation of ores of silver, as at the Spanish mines of Mexico and South America.
MAGISTRAL adjective
  1. Pertaining to or befitting a master; authoritative.
  2. (pharmaceutical effect) Sovereign (of a remedy); extremely effective.
  3. Formulated extemporaneously, or for a special case; opposed to officinal, and said of prescriptions and medicines.

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