Cryptic crossword clue
Mate pointing out natural colouring 12

The most common and most likely answer to this crossword clue is the 12 letter word PIGMENTATION

I've seen this crossword clue in The Times
P
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Buddy explains!

The straight part
We know that "natural colouring" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case natural colouring = pigmentation.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does PIGMENTATION mean?

PIGMENTATION noun
  1. Coloration of human, plant or animal tissue, especially by pigment.

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