The most common and most likely answer to this crossword clue is the 6 plus 7 letter word COCKER SPANIEL
I've seen this crossword clue in The Guardian
C
O
C
K
E
R
S
P
A
N
I
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L
Buddy explains!
The straight part
We know that "man’s best friend" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case man’s best friend = cocker spaniel.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.